Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific (...) and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections. (shrink)

RESUMENLos resultados empíricos y los análisis teóricos en física cuántica ni apoyan ni refutan concluyentemente el realismo. Aunque se mostrara que la interpretación de Copenhague era la única viable de entre todas las posibles, todavía quedaría por probar que con eso se había conculcado cualquier tipo de realismo. Bohr mismo aceptaba un realismo con tintes kantianos y mostraba desagrado hacia el instrumentalismo de Heisenberg. Pero además de la interpretación de Copenhague existen interpretaciones rivales que, a pesar de no estar tan (...) desarrolladas como aquélla, dejan abierto el camino al realismo en la física cuántica. En particular la interpretación de David Bohm.PALABRAS CLAVEREALISMO CIENTIFICO – TEORIA CUANTICA – LOCALIDADABSTRACTThe empirical achievements and theoretical analyses in quantum physics neither support nor refute conclusively realism. Even if it were shown that Copenhagen Interpretation is the only feasible one between all the possible interpretations in quantum mechanics, it would remain to prove that it forbids every kind of realism. In fact, Bohr himself accepted a realism with Kantian aspects and disagreed whith Heisenberg’s instrumentalism. But there are interpretations, rival to Copenhagen’s, which in spite of not being son developped, smooth the way for realism in quantum physics. Particularly David Bohm’s interpretation.KEYWORDSSCIENTIFIC REALISM – QUANTUM THEORY – LOCALITY. (shrink)

Se pretende analizar el concepto de muerte en diversas partes de la filosofía de Schelling, haciendo especial énfasis en las Stuttgarter Privatvorlesungen para establecer que el filósofo emplea este concepto con diversas acepciones, lo cual le lleva a englobar el ámbito de la esencia y de lo ente como ámbitos de muerte siempre con son considerados aisladamente. Ha de haber entre estos dos parámetros una instancia mediadora que conecte estos ámbitos inconmensurables, tratándose en este caso del carácter apofántico del verbo. (...) Esta labor de mediación es la que disuelve la muerte y la que introduce la vida en el espacio que dejan los dos primeros segmentos recíprocos. (shrink)

This book, based on lectures, examines ways that the tradition of 'Middle' Platonism can point us to aspects of Plato's thinking which contemporary discussions often overlook, and which give us a better-rounded account of Plato.

Este artículo propone un análisis de los Aforismos sobre religión y deísmo escritos por J. G. Fichte en 1790, poco antes de su conversión a la filosofía kantiana. Sostenemos que este texto no expresa la adhesión de Fichte al determinismo, ni al punto de vista del corazón, ni tampoco se limita a presentar la religión y el deísmo como dos sistemas opuestos. Según nuestra interpretación, Fichte defiende dos tesis. En primer lugar, que la mezcla de ambos sistemas es inaceptable y (...) hay que respetar el límite que existe entre ellos. En segundo lugar, que es imposible sostener ninguno de los dos sistemas, porque necesariamente entran en colisión y dejan al ser humano en una situación de desgarramiento. La conclusión del fragmento es, por lo tanto, la necesidad de buscar una posición superadora, que logre subsanar la escisión. Esa posición superadora será la Doctrina de la ciencia, que modifica los términos del planteo antagónico y logra la reconciliación de la libertad y la filosofía. This article proposes an analysis of the Aphorisms on Religion and Deism written by J. G. Fichte in 1790, shortly before his conversion to the Kantian philosophy. We argue that this text does not express Fichte’s accordance with determinism, or with the point of view of the heart, nor merely present religion and deism as two opposing systems. According to our interpretation, Fichte defends two theses. First, that the mixture of both systems is unacceptable and the limit between them must be respected. Secondly, that it is impossible to affirm neither of them, because they necessarily collide and leave the human being in a situation of scission. The conclusion of the fragment is, therefore, the need to seek a position that overcomes this situation of scission. That position will be the Doctrine of science, which amends the antagonistic terms of the dilemma and achieves the reconciliation between freedom and philosophy. (shrink)

Corcoran, J. 2005. Counterexamples and proexamples. Bulletin of Symbolic Logic 11(2005) 460. -/- John Corcoran, Counterexamples and Proexamples. Philosophy, University at Buffalo, Buffalo, NY 14260-4150 E-mail: [email protected] Every perfect number that is not even is a counterexample for the universal proposition that every perfect number is even. Conversely, every counterexample for the proposition “every perfect number is even” is a perfect number that is not even. Every perfect number that is odd is a proexample for the existential proposition that some (...) perfect number is odd. Conversely, every proexample for the proposition “some perfect number is odd” is a perfect number that is odd. As trivial these remarks may seem, they can not be taken for granted, even in mathematical and logical texts designed to introduce their respective subjects. One well-reviewed book on counterexamples in analysis says that in order to demonstrate that a universal proposition is false it is necessary and sufficient to construct a counterexample. It is easy to see that it is not necessary to construct a counterexample to demonstrate that the proposition “every true proposition is known to be true” is false–necessity fails. Moreover the mere construction of an object that happens to be a counterexample does not by itself demonstrate that it is a counterexample–sufficiency fails. In order to demonstrate that a universal proposition is false it is neither necessary nor sufficient to construct a counterexample. Likewise, of course, in order to demonstrate that an existential proposition is true it is neither necessary nor sufficient to construct a proexample. This article defines the above relational concepts of counterexample and of proexample, it discusses their surprising history and philosophy, it gives many examples of uses of these and related concepts in the literature and it discusses some of the many errors that have been made as a result of overlooking the challenging subtlety of the proper use of these two basic and indispensable concepts. (shrink)

J. L. Ackrill's work on Plato and Aristotle has had a considerable influence upon ancient philosophical studies in the late twentieth century. In his writings the rigour and clarity of contemporary analytic philosophy are brought to bear upon ancient thought; in many cases he has provided thefirst analytic treatment of a key issue. Gathered now in this volume are the best of Ackrill's essays on the two greatest philosophers of antiquity. With philosophical acuity and philological expertise he examines a wide (...) range of texts and topics--from ethics and logic to epistemology andmetaphysics--which continue to be in the focus of debate. (shrink)

The definition of acedia presents unique conceptual problems among the eight Evagrian logismoi. Its descriptions are so complex and varied as to render the concept seemingly incoherent. This article argues that the conceptual unity of acedia has been obscured by the translation of Evagrian logismoi into the ‘deadly sins’ tradition, resulting in a category error. Acedia is more properly understood, not as a psychological state or a sin, but rather as an array of demonic temptations with the unifying end-goal of (...) interrupting the anchoritic ideal of sustained contemplation. (shrink)

This paper studies the problem of the arrow of time from the scientific and philosophical perspective. The scientific section (Castagnino) poses the topic according to the instruments of measuring employed in physical theories, specially when they are applied to dynamic chaotic systems in which a temporal asymmetry is shown. From the analysis of “two schools” (epistemological and ontological), the conclusion is favorable to the reality (both ontological and epistemological) of the difference between past and future, with the recourse to Reichenbach’s (...) notion of global system. In the philosophical section (Sanguineti) the content of the scientific part of the article is presented in a qualitative way. The role of some philosophical choices in the scientific field is stressed, taking into account the diversity of a positivistic and realistic view. (shrink)

Although the theory of definability had many important antecedents—such as the descriptive set theory initiated by the French semi-intuitionists in the early 1900s—the main ideas were first laid out in precise mathematical terms by Alfred Tarski beginning in 1929. We review here the basic notions of languages, explicit definability, and grammatical complexity, and emphasize common themes in the theories of definability for four important languages underlying, respectively, descriptive set theory, recursive function theory, classical pure logic, and finite-universe logic. We review (...) the history of previous studies of the similarities and differences in the theories of definability of the first three of these four languages. A seminal role leading toward unification of the theories has been played by the separation principles introduced by Nikolai Luzin in 1927. Emphasizing analogies and driving toward further unification embracing finite-universe logic we concentrate on a simple example—the first and second separation principles for existential-universal first-order sentences . Using this as a test case for the fundamental problem of how to “finitize” arguments in classical pure logic to the finite-universe case, we are led to the analogous negative solution by using the theory of certain special graphs: a graph is - special for any positive integers m , n , p , q iff it is bipartite with m red points and n blue points and for every p -tuple of red points there is a blue point to which they are all connected . As an aside we introduce for further study a natural “Ramseyesque” increasing sequence A of positive integers, where A is the least positive integer n for which an -special graph exists. (shrink)