Emergence of the novel pathogenic coronavirus SARS‐CoV‐2 and its rapid pandemic spread presents challenges that demand immediate attention. Here, we describe the development of a semi‐quantitative high‐content microscopy‐based assay for detection of three major classes (IgG, IgA, and IgM) of SARS‐CoV‐2 specific antibodies in human samples. The possibility to detect antibodies against the entire viral proteome together with a robust semi‐automated image analysis workflow resulted in specific, sensitive and unbiased assay that complements the portfolio of SARS‐CoV‐2 serological assays. Sensitive, specific (...) and quantitative serological assays are urgently needed for a better understanding of humoral immune response against the virus as a basis for developing public health strategies to control viral spread. The procedure described here has been used for clinical studies and provides a general framework for the application of quantitative high‐throughput microscopy to rapidly develop serological assays for emerging virus infections. (shrink)

RESUMENLos resultados empíricos y los análisis teóricos en física cuántica ni apoyan ni refutan concluyentemente el realismo. Aunque se mostrara que la interpretación de Copenhague era la única viable de entre todas las posibles, todavía quedaría por probar que con eso se había conculcado cualquier tipo de realismo. Bohr mismo aceptaba un realismo con tintes kantianos y mostraba desagrado hacia el instrumentalismo de Heisenberg. Pero además de la interpretación de Copenhague existen interpretaciones rivales que, a pesar de no estar tan (...) desarrolladas como aquélla, dejan abierto el camino al realismo en la física cuántica. En particular la interpretación de David Bohm.PALABRAS CLAVEREALISMO CIENTIFICO – TEORIA CUANTICA – LOCALIDADABSTRACTThe empirical achievements and theoretical analyses in quantum physics neither support nor refute conclusively realism. Even if it were shown that Copenhagen Interpretation is the only feasible one between all the possible interpretations in quantum mechanics, it would remain to prove that it forbids every kind of realism. In fact, Bohr himself accepted a realism with Kantian aspects and disagreed whith Heisenberg’s instrumentalism. But there are interpretations, rival to Copenhagen’s, which in spite of not being son developped, smooth the way for realism in quantum physics. Particularly David Bohm’s interpretation.KEYWORDSSCIENTIFIC REALISM – QUANTUM THEORY – LOCALITY. (shrink)

Se pretende analizar el concepto de muerte en diversas partes de la filosofía de Schelling, haciendo especial énfasis en las Stuttgarter Privatvorlesungen para establecer que el filósofo emplea este concepto con diversas acepciones, lo cual le lleva a englobar el ámbito de la esencia y de lo ente como ámbitos de muerte siempre con son considerados aisladamente. Ha de haber entre estos dos parámetros una instancia mediadora que conecte estos ámbitos inconmensurables, tratándose en este caso del carácter apofántico del verbo. (...) Esta labor de mediación es la que disuelve la muerte y la que introduce la vida en el espacio que dejan los dos primeros segmentos recíprocos. (shrink)

Este artículo propone un análisis de los Aforismos sobre religión y deísmo escritos por J. G. Fichte en 1790, poco antes de su conversión a la filosofía kantiana. Sostenemos que este texto no expresa la adhesión de Fichte al determinismo, ni al punto de vista del corazón, ni tampoco se limita a presentar la religión y el deísmo como dos sistemas opuestos. Según nuestra interpretación, Fichte defiende dos tesis. En primer lugar, que la mezcla de ambos sistemas es inaceptable y (...) hay que respetar el límite que existe entre ellos. En segundo lugar, que es imposible sostener ninguno de los dos sistemas, porque necesariamente entran en colisión y dejan al ser humano en una situación de desgarramiento. La conclusión del fragmento es, por lo tanto, la necesidad de buscar una posición superadora, que logre subsanar la escisión. Esa posición superadora será la Doctrina de la ciencia, que modifica los términos del planteo antagónico y logra la reconciliación de la libertad y la filosofía. This article proposes an analysis of the Aphorisms on Religion and Deism written by J. G. Fichte in 1790, shortly before his conversion to the Kantian philosophy. We argue that this text does not express Fichte’s accordance with determinism, or with the point of view of the heart, nor merely present religion and deism as two opposing systems. According to our interpretation, Fichte defends two theses. First, that the mixture of both systems is unacceptable and the limit between them must be respected. Secondly, that it is impossible to affirm neither of them, because they necessarily collide and leave the human being in a situation of scission. The conclusion of the fragment is, therefore, the need to seek a position that overcomes this situation of scission. That position will be the Doctrine of science, which amends the antagonistic terms of the dilemma and achieves the reconciliation between freedom and philosophy. (shrink)

J. L. Ackrill's work on Plato and Aristotle has had a considerable influence upon ancient philosophical studies in the late twentieth century. In his writings the rigour and clarity of contemporary analytic philosophy are brought to bear upon ancient thought; in many cases he has provided thefirst analytic treatment of a key issue. Gathered now in this volume are the best of Ackrill's essays on the two greatest philosophers of antiquity. With philosophical acuity and philological expertise he examines a wide (...) range of texts and topics--from ethics and logic to epistemology andmetaphysics--which continue to be in the focus of debate. (shrink)

The definition of acedia presents unique conceptual problems among the eight Evagrian logismoi. Its descriptions are so complex and varied as to render the concept seemingly incoherent. This article argues that the conceptual unity of acedia has been obscured by the translation of Evagrian logismoi into the ‘deadly sins’ tradition, resulting in a category error. Acedia is more properly understood, not as a psychological state or a sin, but rather as an array of demonic temptations with the unifying end-goal of (...) interrupting the anchoritic ideal of sustained contemplation. (shrink)

Although the theory of definability had many important antecedents—such as the descriptive set theory initiated by the French semi-intuitionists in the early 1900s—the main ideas were first laid out in precise mathematical terms by Alfred Tarski beginning in 1929. We review here the basic notions of languages, explicit definability, and grammatical complexity, and emphasize common themes in the theories of definability for four important languages underlying, respectively, descriptive set theory, recursive function theory, classical pure logic, and finite-universe logic. We review (...) the history of previous studies of the similarities and differences in the theories of definability of the first three of these four languages. A seminal role leading toward unification of the theories has been played by the separation principles introduced by Nikolai Luzin in 1927. Emphasizing analogies and driving toward further unification embracing finite-universe logic we concentrate on a simple example—the first and second separation principles for existential-universal first-order sentences . Using this as a test case for the fundamental problem of how to “finitize” arguments in classical pure logic to the finite-universe case, we are led to the analogous negative solution by using the theory of certain special graphs: a graph is - special for any positive integers m , n , p , q iff it is bipartite with m red points and n blue points and for every p -tuple of red points there is a blue point to which they are all connected . As an aside we introduce for further study a natural “Ramseyesque” increasing sequence A of positive integers, where A is the least positive integer n for which an -special graph exists. (shrink)

In Not God Enough, J.D. Greear explains that the thing between you and the vibrant faith you want isn't answers to all our spiritual questions, but an escape from the small God we've imagined in place of an actual encounter with the real, awesome, glorious God of the Bible.

This chapter contains sections titled: Notes.

Introduction, by J. L. Hevesi.--Days of reading, by M. Proust.--Poetry and abstract thought, by P. Valèry.--Jacob Cow the pirate; or, Whether words are signs, by J. Paulhan.--Concerning the pebble, by F. Ponge.--The journey and the return, by J. P. Sartre.--The power of words, by B. Parain.

In ‘Minds, Machines and Gödel’, 1961, J. R. Lucas proposed that Godel's theorem made possible a refutation of mechanism—the thesis that mind is wholly comprehensible as a consistent, rule-governed machine. A sympathetic reading of Lucas's argument might run something as follows: ‘If I am a machine then it will be possible in principle to give a specification of the consistent formal system, L, that represents me. If this formal system were handed to me, I would be able to prove a (...) Gödel sentence, G, which L could not generate—that is, L could not model my proving G. But since I have proved G, L is inadequate as a model of my cognitive process.’. (shrink)

With an intellectual autobiography by Hans J. Morgenthau.

This article gives new information about the social, cultural, and political beliefs of Thomas Wilson, the first Secretary and Treasurer of the Yorkshire Geological and Polytechnic Society founded in 1837. Wilson's private correspondence was not available to J. W. Davis, who wrote the standard history of the Society to celebrate its jubilee. Davis's history underestimates the part played by Wilson and overestimates the importance of Thomas William Embleton, whose private papers were placed at Davis's disposal. It is shown that Wilson, (...) and not Embleton, was the driving force in forming and consolidating the Society, especially with respect to its early difficulties in defining even its title and aims. (shrink)

Retrospective rule-making has few supporters and many opponents. Defenders of retrospective laws generally do so on the basis that they are a necessary evil in specific or limited circumstances, for example to close tax loopholes, to deal with terrorists or to prosecute fallen tyrants. Yet the reality of retrospective rule making is far more widespread than this, and ranges from ’corrective’ legislation to ’interpretive regulations’ to judicial decision making. The search for a rational justification for retrospective rule-making necessitates a reconsideration (...) of the very nature of the rule of law and the kind of law that can rule, and will provide new insights into the nature of law and the parameters of societal order. This book examines the various ways in which laws may be seen as retrospective and analyses the problems in defining retrospectivity. In his analysis Dr Charles Sampford asserts that the definitive argument against retrospective rule-making is the expectation of individuals that, if their actions today are considered by a future court, the applicable law was discoverable at the time the action was performed. The book goes on to suggest that although the strength of this ’rule of law’ argument should prevail in general, exceptions are sometimes necessary, and that there may even be occasions when analysis of the rule of law may provide the foundation for the application of retrospective laws. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 121.2 (2000) 279-289 [Access article in PDF] Dice and Facie: Quintilian, Institutio Oratoria 1.7.23 And 9.4.39 J. Bradford Churchill In his discussion of orthography in book 1 of his Institutio Oratoria Quintilian mentions several examples of archaic spelling conventions, among them a practice of the Elder Cato, which I present here with readings I shall propose and defend during the course of this essay: Non (...) Cato Censorius dicam et faciam dice et facie scripsit eundemque in ceteris quae similiter cadunt modum tenuit? (Inst. 1.7.23 5 Cato, Inc. Lib. fr. 55 Jordan, p. 90) Dice et facie is the reading of one manuscript (N); two other manuscripts (BH) have dicae et faciae; the other major manuscripts (APMS) have the similar but obviously corrupt dice et face. The vast discrepancies between the readings accepted by various editors demonstrate the need for a clarification of the evidence: dice et facie; 1 dicem et faciem; 2 dicae et faciae; 3. 4 The reading dicae et faciae found its way into the most recent edition, the Oxford Classical Text of Michael Winterbottom ([1970] 1989). A close examination of the evidence will confirm that this is not the correct reading. It is time to put to rest a good deal of needless controversy by showing that Cato and his contemporaries used a distinct first-person form in the future indicative of the third conjugation and that they usually or always spelled the active form without the final -m. The reading dice et facie accepted by Radermacher (1959), Fierville (1890), and Halm (1869, 367) should stand. [End Page 279]A century ago (1898) Moore argued, in a brief note influential enough to be cited in Winterbottom's apparatus, that behind Quintilian's citation as preserved lies an innovative orthographical practice not otherwise attested. Moore constructed his hypothesis on the assumption that the variants adduced were simply different ways of spelling the forms dicam and faciam. 5 Cato was not satisfied, Moore proposed, simply to follow the usual practice of the time and omit spelling the final -m, which was in many environments only partly articulated. Since the -m did, however, have some impact on the sound, Cato invented a new custom, turning M on its side at the end of the word to indicate the nasal quality of the final vowel. This anomalous symbol was preserved by Quintilian but later misconstrued as E. In this way Moore attempted to render the otherwise nonsensical forms dicae and faciae comprehensible as textual corruptions of Cato's innovation.Klotz (1931) dealt in greater depth with the problem, and although his solution is almost certainly inadequate, he touched on most of the evidence needed to solve it. Because Quintilian quotes Cato's archaic spelling convention again in book 9 (Inst. 9.4.39) in a discussion of sounds which are not spelled, Klotz conjectured (142) that Verrius Flaccus had quoted Cato as a precedent for his own practice of indicating the attenuated pronunciation of an elided final -m by writing only the first half of the letter. So, Klotz's argument continues, it was from Verrius Flaccus (GL 7.80) that Messala drew the example, and from him Quintilian derived the extant version. The "half-M" was misconstrued by Quintilian as E, and so the textual tradition preserves what he wrote: dicae et faciae.Both Moore and Klotz have read Quintilian too narrowly. Each of their arguments is predicated on the assumption (in Moore's case) or argument (in Klotz's) that Cato's forms were morphologically identical to Quintilian's dicam and faciam. They dismissed the possibility that Cato was spelling forms distinct from the classical counterparts listed by Quintilian. This is not a surprising dismissal: among the examples cited by Quintilian, these are the only ones which turn out (if the current argument is accepted) to have been morphologically distinct from the [End Page 280] classical "equivalents." Nevertheless, a careful examination of all the evidence, and in particular a close reading of the cognate passage... (shrink)

Carl Schmitt was the most famous and controversial defender of political theology in the twentieth century. But in his best-known work, _The Concept of the Political_, issued in 1927, 1932, and 1933, political considerations led him to conceal the dependence of his political theory on his faith in divine revelation. In 1932 Leo Strauss published a critical review of _Concept _that initiated an extremely subtle exchange between Schmitt and Strauss regarding Schmitt’s critique of liberalism. Although Schmitt never answered Strauss publicly, (...) in the third edition of his book he changed a number of passages in response to Strauss’s criticisms. Now, in this elegant translation by J. Harvey Lomax, Heinrich Meier shows us what the remarkable dialogue between Schmitt and Strauss reveals about the development of these two seminal thinkers. Meier contends that their exchange only ostensibly revolves around liberalism. At its heart, their “hidden dialogue” explores the fundamental conflict between political theology and political philosophy, between revelation and reason­and ultimately, the vital question of how human beings ought to live their lives. “Heinrich Meier’s treatment of Schmitt’s writings is morally analytical without moralizing, a remarkable feat in view of Schmitt’s past. He wishes to understand what Schmitt was after rather than to dismiss him out of hand or bowdlerize his thoughts for contemporary political purposes.”—Mark Lilla, _New York__ Review of Books _. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:714 BOOK REVIEWS learning; the Jesuits lean to the voluntarist. Possessed of a unitary academic model, he is really arguing for Aristotle's analogy of attribution. Apparently, no one of his 200 plus Jesuit contacts told him that Nastri prefer St. Thomas and his analogy of proper proportionality. The historian Daniel Boorstin spent 25 yeari!l writing his trilogy on The Americans. What emerges from this analysis? Boorstin points out that (...) Americans like ambiguity, that they function best amid flux; ambivalence becomes their proper medium. For this reason, I have accepted Nathaniel Hawthorne as our most central writer. He situates American questions within a landscape of chiaroscuro. The Jesuit experience in the United States belongs essentially to the same landscape. But today, as formerly, it remains a landscape of questions. McDonough, on the other hand, has too many certitudes, too many answers, too much high definition-what Henry Adams regards as "mere facts." Instead of illuminating the landscape from within, his study inevitably recedes into the larger ambiguity reserved for what Wallace Stevens has called, " Prologues to what is possible." Saint Paul University Ottawa, Ontario JOHN P. McINTYRE, S.J. The Dilemma of Freedom and Foreknowledge. By LINDA TRINKAUS ZAGZEBSKI. New York: Oxford University Press, 1991. viii + 215 pp. $29.95. As a Christian and a philosopher, Linda Trinkaus Zagzebski wants to understand why it is reasonable to affirm that we remain free despite God's infallible knowledge of our future acts. Moreover, she is not content simply to demonstrate that this affirmation involves no logical con· tradiction, for "reasonable people expect more" (p. 33) than a merely negative result. Hence the author sets herself the more ambitious task of working toward a positive solution that would explain why the compatibility of divine foreknowledge and human freedom is plausible and not a bare logical possibility. The hook sorts out recent opinions on the subject and sketches an original position that she hopes will advance the discussion. Zagzehski begins by constructing the most formidable version of the dilemma. Assuming that God is infallible and essentially omniscient, that the past has a kind of necessity that the future lacks ("accidental necessity"), and that this necessity can he transferred (in some sense) from the antecedent to the consequent of a conditional proposition, the dilemma may he stated as follows: BOOK REVIEWS (1) Necessarily, God believes at time t 1 that I will do S at t 3 if and only if I do S at t 3. (2) It is accidentally necessary at t 2 that God believes at t 1 that I will do S at t 3. (3) If (1) and (2) are true, then it is accidentally necessary at t 2 that I do Sat t 3. (4) It follows that it is accidentally necessary at t 2 that I do S at t 3. (5) But if it is accidentally necessary at t 2 that I do S at t 3, I do not do S at t 3 freely. (6) Therefore, I do not do S at t 3 freely. 715 Much of the first chapter is devoted to establishing that this form of the dilemma is more resistant to solution than any other, especially the so-called problem of future truth. Zagzebski goes on to evaluate three broad approaches to solving the dilemma. In Chapter 2 she takes up the " timelessness " solution. Its proponents, among whom the author numbers Boethius, Thomas Aquinas, Eleonore Stump, and Norman Kretzmann, negate premise (2) of the foreknowledge dilemma by contending that God is not in time. Zagzebski considers this an acceptable negative solution to the dilemma and sees in it the potential to ground a more comprehensive, positive solution. Nonetheless, she refrains from subscribing wholeheartedly to the timelessness solution because it confronts one with a dilemma at least as perplexing as the one it solves. She puts the problem this way: like the past, eternity is fixed, for it is constituted by a state of affairs about which we cannot do anything; therefore my future acts are determined no less by God's timeless knowledge than by God's foreknowing them in a strictly temporal sense. In Chapter 3, Zagzebski considers... (shrink)

High quality images sell products. Here's how you do it. From cereal boxes to billboards to photos on Amazon, product photos have a strong impact on viewers. Now you can master the secrets of effective product photography with this essential guide. Author J. Dennis Thomas guides you through the basics, from selecting the right equipment and practicing different lighting techniques to controlling exposure, using backgrounds and props, and much more. Whether it's jewelry, food, fashion, or other products, learn how to (...) photograph for effective selling, while building the skills and tools you need for a career. Explains how to produce quality photos for product or commercial photography, including fashion, food, jewelry, technology, and more The author is a professional photographer whose work has been published in major U.S. magazines including Rolling Stone, Elle, W Magazine, and US Weekly Covers choosing the right equipment, practicing different lighting techniques, controlling exposure, using backgrounds and props, and more Gives new and even experienced photographers the tools they need to build careers in product photography Take photographs that impress, intrigue, dazzle, and sell with The Art and Style of Product Photography. (shrink)

It would be a mistake to attempt to identify in modern terms the disease of Galerius described so graphically by Lactantius, Mort. 33. Consumption by lice or worms, if not genital ‘gangrene’, was a typical end for a tyrant or the impious, and there must be an element of literary exaggeration in Lactantius' account. But whatever one makes of the nature of the illness, Lactantius did set out to give the passage a scientific plausibility by his use of technical medical (...) phraseology, and by an allusion to a medical theory at 33.7. Recognition of this theory allows one to settle the text at one point, where editors have failed to agree. There is also a second place in the chapter where familiarity with medical Latin points one towards the solution of a textual problem. (shrink)

The demonstration by E. Wölfflin that between theHistoriesandAnnalsTacitus progressed towards a more archaic and artificial style is well known. From the outset Tacitus adhered to the traditional Roman view that history should be composed in an archaic language remote from everyday usage ; but he was apparently at first not fully aware of the possibilities of the archaizing style. New archaisms and artificial usages suggested themselves as he advanced ; and others, which he had used sporadically even early in theHistories, (...) were allowed to oust ordinary alternatives completely. (shrink)